Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae.

Pneumolysin is the thiol-activated cytolysin produced by Streptococcus pneumoniae. Mice were immunized with a genetically engineered toxoid version of pneumolysin, which was derived from a serotype 2 pneumococcus. The toxoid carried the mutation Trp-433-->Phe. Alum was used as the adjuvant. Immunize...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Alexander, J E, Lock, R A, Peeters, C C, Poolman, J T, Andrew, P W, Mitchell, T J, Hansman, D, Paton, J C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303321/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7960154/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.12.5683-5688.1994
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