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Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase

It is well established that many cell functions are controlled by the PI-3K signaling pathway and the signaling lipid, phosphatidylinositol-3,4,5-triphosphate (PIP3). This is particularly true for mast cells which play a key regulatory role in allergy and inflammation through activation via high-aff...

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Hlavní autoři: Shenker, Bruce J., Boesze-Battaglia, Kathleen, Zekavat, Ali, Walker, Lisa, Besack, Dave, Ali, Hydar
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993869/
https://ncbi.nlm.nih.gov/pubmed/20863570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.08.009
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