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Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells
The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 (NF1). The development of neurofibromas, which are complex tumors composed of multiple cell types, is a hallmark of NF1. Som...
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| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC296994/ https://ncbi.nlm.nih.gov/pubmed/14679180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200319195 |
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