Hyperactivation of P21(ras) and the Hematopoietic-Specific Rho Gtpase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-Deficient Mast Cells in Vivo and in Vitro

Mutations in the NF1 tumor suppressor gene cause neurofibromatosis type I (NF1), a disease characterized by the formation of cutaneous neurofibromas infiltrated with a high density of degranulating mast cells. A hallmark of cell lines generated from NF1 patients or Nf1-deficient mice is their propen...

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Bibliografiske detaljer
Main Authors: Ingram, David A., Hiatt, Kelly, King, Alastair J., Fisher, Lucy, Shivakumar, Rama, Derstine, Christina, Wenning, Mary Jo, Diaz, Bruce, Travers, Jeffrey B., Hood, Antoinette, Marshall, Mark, Williams, David A., Clapp, D. Wade
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2001
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193446/
https://ncbi.nlm.nih.gov/pubmed/11435472
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