Genetic and Biochemical Evidence That Haploinsufficiency of the Nf1 Tumor Suppressor Gene Modulates Melanocyte and Mast Cell Fates in Vivo

Neurofibromatosis type 1 (NF1) is a common autosomal-dominant disorder characterized by cutaneous neurofibromas infiltrated with large numbers of mast cells, melanocyte hyperplasia, and a predisposition to develop malignant neoplasms. NF1 encodes a GTPase activating protein (GAP) for Ras. Consistent...

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Detalhes bibliográficos
Main Authors: Ingram, David A., Yang, Feng-Chun, Travers, Jeffrey B., Wenning, Mary Jo, Hiatt, Kelly, New, Sheryl, Hood, Antoinette, Shannon, Kevin, Williams, David A., Clapp, D. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2000
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195790/
https://ncbi.nlm.nih.gov/pubmed/10620616
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