Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells

The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 (NF1). The development of neurofibromas, which are complex tumors composed of multiple cell types, is a hallmark of NF1. Som...

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Pubblicato in:J Clin Invest
Autori principali: Feng-Chun, Yang, Ingram, David A., Chen, Shi, Hingtgen, Cynthia M., Ratner, Nancy, Monk, Kelly R., Clegg, Travis, White, Hilary, Mead, Laura, Wenning, Mary Jo, Williams, David A., Kapur, Reuben, Atkinson, Simon J., Clapp, D. Wade
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2003
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Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296994/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14679180/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI19195
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