Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells

The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 (NF1). The development of neurofibromas, which are complex tumors composed of multiple cell types, is a hallmark of NF1. Som...

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Bibliographische Detailangaben
Hauptverfasser: Feng-Chun, Yang, Ingram, David A., Chen, Shi, Hingtgen, Cynthia M., Ratner, Nancy, Monk, Kelly R., Clegg, Travis, White, Hilary, Mead, Laura, Wenning, Mary Jo, Williams, David A., Kapur, Reuben, Atkinson, Simon J., Clapp, D. Wade
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC296994/
https://ncbi.nlm.nih.gov/pubmed/14679180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200319195
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