Hyperactivation of P21(ras) and the Hematopoietic-Specific Rho Gtpase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-Deficient Mast Cells in Vivo and in Vitro

Mutations in the NF1 tumor suppressor gene cause neurofibromatosis type I (NF1), a disease characterized by the formation of cutaneous neurofibromas infiltrated with a high density of degranulating mast cells. A hallmark of cell lines generated from NF1 patients or Nf1-deficient mice is their propen...

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Detalhes bibliográficos
Main Authors: Ingram, David A., Hiatt, Kelly, King, Alastair J., Fisher, Lucy, Shivakumar, Rama, Derstine, Christina, Wenning, Mary Jo, Diaz, Bruce, Travers, Jeffrey B., Hood, Antoinette, Marshall, Mark, Williams, David A., Clapp, D. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193446/
https://ncbi.nlm.nih.gov/pubmed/11435472
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