Tumor-specific CD8+ T cells expressing IL-12 eradicate established cancers in lymphodepleted hosts

T-cell based immunotherapies can be effective in the treatment of large vascularized tumors, but they rely on adoptive transfer of substantial numbers (~ 20 million) of tumor-specific T cells administered together with vaccination and high-dose IL-2. In this study, we report that ~10,000 T cells gen...

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Bibliografiske detaljer
Main Authors: Kerkar, Sid P, Muranski, Pawel, Kaiser, Andrew, Boni, Andrea, Sanchez-Perez, Luis, Yu, Zhiya, Palmer, Douglas C, Reger, Robert N, Borman, Zachary A, Zhang, Ling, Morgan, Richard A, Gattinoni, Luca, Rosenberg, Steven A, Trinchieri, Giorgio, Restifo, Nicholas P
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935308/
https://ncbi.nlm.nih.gov/pubmed/20647327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0735
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