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Local Delivery of lnterleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice

PURPOSE: We investigated the feasibility of delivering the proinflammatory cytokine interleukin (IL)-12 into tumor using T cells genetically engineered to express a chimeric antigen receptor (CAR) against the VEGF receptor-2 (VEGFR-2). EXPERIMENTAL DESIGN: Two different strains of mice bearing five...

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Bibliografski detalji
Izdano u:Clin Cancer Res
Glavni autori: Chinnasamy, Dhanalakshmi, Yu, Zhiya, Kerkar, Sid P., Zhang, Ling, Morgan, Richard A., Restifo, Nicholas P., Rosenberg, Steven A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390958/
https://ncbi.nlm.nih.gov/pubmed/22291136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3050
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