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Tumor-specific CD8+ T cells expressing IL-12 eradicate established cancers in lymphodepleted hosts
T-cell based immunotherapies can be effective in the treatment of large vascularized tumors, but they rely on adoptive transfer of substantial numbers (~ 20 million) of tumor-specific T cells administered together with vaccination and high-dose IL-2. In this study, we report that ~10,000 T cells gen...
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| Hlavní autoři: | , , , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2935308/ https://ncbi.nlm.nih.gov/pubmed/20647327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0735 |
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