Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice

Immunotherapies based on adoptive cell transfer are highly effective in the treatment of metastatic melanoma, but the use of this approach in other cancer histologies has been hampered by the identification of appropriate target molecules. Immunologic approaches targeting tumor vasculature provide a...

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Hauptverfasser: Chinnasamy, Dhanalakshmi, Yu, Zhiya, Theoret, Marc R., Zhao, Yangbing, Shrimali, Rajeev K., Morgan, Richard A., Feldman, Steven A., Restifo, Nicholas P., Rosenberg, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964987/
https://ncbi.nlm.nih.gov/pubmed/20978347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43490
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