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Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice

Immunotherapies based on adoptive cell transfer are highly effective in the treatment of metastatic melanoma, but the use of this approach in other cancer histologies has been hampered by the identification of appropriate target molecules. Immunologic approaches targeting tumor vasculature provide a...

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Autors principals: Chinnasamy, Dhanalakshmi, Yu, Zhiya, Theoret, Marc R., Zhao, Yangbing, Shrimali, Rajeev K., Morgan, Richard A., Feldman, Steven A., Restifo, Nicholas P., Rosenberg, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964987/
https://ncbi.nlm.nih.gov/pubmed/20978347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43490
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