Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment

Interleukin-12 (IL-12) is an important immunostimulatory cytokine, yet its clinical application has been limited by the systemic toxicity associated with its administration. In this work, we developed a strategy to selectively deliver IL-12 to the tumor environment using genetically engineered lymph...

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Detalhes bibliográficos
Main Authors: Zhang, Ling, Kerkar, Sid P, Yu, Zhiya, Zheng, Zhili, Yang, Shicheng, Restifo, Nicholas P, Rosenberg, Steven A, Morgan, Richard A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070103/
https://ncbi.nlm.nih.gov/pubmed/21285960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.313
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