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Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment
Interleukin-12 (IL-12) is an important immunostimulatory cytokine, yet its clinical application has been limited by the systemic toxicity associated with its administration. In this work, we developed a strategy to selectively deliver IL-12 to the tumor environment using genetically engineered lymph...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070103/ https://ncbi.nlm.nih.gov/pubmed/21285960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.313 |
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