Collapse of the Tumor Stroma is Triggered by IL-12 Induction of Fas

Engineering CD8(+) T cells to deliver interleukin 12 (IL-12) to the tumor site can lead to striking improvements in the ability of adoptively transferred T cells to induce the regression of established murine cancers. We have recently shown that IL-12 triggers an acute inflammatory environment that...

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Autores principales: Kerkar, Sid P, Leonardi, Anthony J, van Panhuys, Nicolas, Zhang, Ling, Yu, Zhiya, Crompton, Joseph G, Pan, Jenny H, Palmer, Douglas C, Morgan, Richard A, Rosenberg, Steven A, Restifo, Nicholas P
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702103/
https://ncbi.nlm.nih.gov/pubmed/23568260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.58
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