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Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
Gene targeting by homologous recombination in embryonic stem cells is extensively used to generate specific mouse mutants. However, most mammalian species lack tools for targeted gene manipulation. Since double-strand breaks strongly increase the rate of homologous recombination at genomic loci, we...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930558/ https://ncbi.nlm.nih.gov/pubmed/20686113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009424107 |
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