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Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
The study of genetic disease mechanisms relies mostly on targeted mouse mutants that are derived from engineered embryonic stem (ES) cells. Nevertheless, the establishment of mutant ES cells is laborious and time-consuming, restricting the study of the increasing number of human disease mutations di...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593923/ https://ncbi.nlm.nih.gov/pubmed/23426636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218721110 |
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