Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

The study of genetic disease mechanisms relies mostly on targeted mouse mutants that are derived from engineered embryonic stem (ES) cells. Nevertheless, the establishment of mutant ES cells is laborious and time-consuming, restricting the study of the increasing number of human disease mutations di...

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Bibliografiske detaljer
Main Authors: Wefers, Benedikt, Meyer, Melanie, Ortiz, Oskar, Hrabé de Angelis, Martin, Hansen, Jens, Wurst, Wolfgang, Kühn, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593923/
https://ncbi.nlm.nih.gov/pubmed/23426636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218721110
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