Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Cellular senescence has been recently shown to play an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or loss of tumour suppressor genes is thought to critically dependent on the induction of the p19Arf-p53 pathway. The Skp2 E3-ubiquitin ligase can act as...

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Main Authors: Lin, Hui-Kuan, Chen, Zhenbang, Wang, Guocan, Nardella, Caterina, Lee, Szu-Wei, Chan, Chia-Hsin, Yang, Wei-Lei, Wang, Jing, Egia, Ainara, Nakayama, Keiichi I., Cordon-Cardo, Carlos, Teruya-Feldstein, Julie, Pandolfi, Pier Paolo
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928066/
https://ncbi.nlm.nih.gov/pubmed/20237562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08815
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