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Bivalent Diketopiperazine-based Tropomysin Receptor Kinase C (TrkC) Antagonists

Bivalent molecules containing two β-turn mimics with side-chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.

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Hlavní autoři: Liu, Jing, Brahimi, Fouad, Saragovi, H. Uri, Burgess, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907676/
https://ncbi.nlm.nih.gov/pubmed/20540510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100148d
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