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Bivalent Diketopiperazine-based Tropomysin Receptor Kinase C (TrkC) Antagonists
Bivalent molecules containing two β-turn mimics with side-chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2907676/ https://ncbi.nlm.nih.gov/pubmed/20540510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100148d |
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