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A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist
BACKGROUND: Receptor tyrosine kinases (RTK) act through dimerization. Previously it was thought that only bivalent ligands could be agonistic, whereas monovalent ligands should be antagonistic. This notion changed after the demonstration that monovalent ligands can be agonistic, including our report...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943489/ https://ncbi.nlm.nih.gov/pubmed/20600627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2010.06.007 |
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