A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist

BACKGROUND: Receptor tyrosine kinases (RTK) act through dimerization. Previously it was thought that only bivalent ligands could be agonistic, whereas monovalent ligands should be antagonistic. This notion changed after the demonstration that monovalent ligands can be agonistic, including our report...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Brahimi, Fouad, Liu, Jing, Malakhov, Andrey, Chowdhury, Shafinaz, Purisima, Enrico O., Ivanisevic, Ljubica, Caron, Antoine, Burgess, Kevin, Saragovi, H. Uri
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943489/
https://ncbi.nlm.nih.gov/pubmed/20600627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2010.06.007
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker