A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist

BACKGROUND: Receptor tyrosine kinases (RTK) act through dimerization. Previously it was thought that only bivalent ligands could be agonistic, whereas monovalent ligands should be antagonistic. This notion changed after the demonstration that monovalent ligands can be agonistic, including our report...

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Hlavní autoři: Brahimi, Fouad, Liu, Jing, Malakhov, Andrey, Chowdhury, Shafinaz, Purisima, Enrico O., Ivanisevic, Ljubica, Caron, Antoine, Burgess, Kevin, Saragovi, H. Uri
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943489/
https://ncbi.nlm.nih.gov/pubmed/20600627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2010.06.007
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