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Bivalent Diketopiperazine-based Tropomysin Receptor Kinase C (TrkC) Antagonists
Bivalent molecules containing two β-turn mimics with side-chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.
Wedi'i Gadw mewn:
| Prif Awduron: | , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2010
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2907676/ https://ncbi.nlm.nih.gov/pubmed/20540510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100148d |
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