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TrkC-Targeted Kinase Inhibitors And PROTACs

A small molecule motif (IY–IY), which binds the tropomyosin receptor kinase C (TrkC), was used to deliver the promiscuous kinase inhibitor (KI) dasatinib into breast cancer. Conjugates with noncleavable (1) and cleavable (2) linkers were compared in cellular assays and shown to have more impact on t...

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Podrobná bibliografie
Vydáno v:Mol Pharm
Hlavní autoři: Zhao, Bosheng, Burgess, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034693/
https://ncbi.nlm.nih.gov/pubmed/31512882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00673
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