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TrkC-Targeted Kinase Inhibitors And PROTACs

A small molecule motif (IY–IY), which binds the tropomyosin receptor kinase C (TrkC), was used to deliver the promiscuous kinase inhibitor (KI) dasatinib into breast cancer. Conjugates with noncleavable (1) and cleavable (2) linkers were compared in cellular assays and shown to have more impact on t...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Zhao, Bosheng, Burgess, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034693/
https://ncbi.nlm.nih.gov/pubmed/31512882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00673
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