Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

New drugs are needed to treat toxoplasmosis. Toxoplasma gondii calcium-dependent protein kinases (TgCDPKs) are attractive targets because they are absent in mammals. We show that TgCDPK1 is inhibited by low nanomolar levels of bumped kinase inhibitors (BKIs), compounds designed to be inactive agains...

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書誌詳細
主要な著者: Ojo, Kayode K, Larson, Eric T, Keyloun, Katelyn R, Castaneda, Lisa J, DeRocher, Amy E, Inampudi, Krishna K, Kim, Jessica E, Arakaki, Tracy L, Murphy, Ryan C, Zhang, Li, Napuli, Alberto J, Maly, Dustin J, Verlinde, Christophe LMJ, Buckner, Frederick S, Parsons, Marilyn, Hol, Wim GJ, Merritt, Ethan A, Van Voorhis, Wesley C
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896873/
https://ncbi.nlm.nih.gov/pubmed/20436472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1818
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