Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

New drugs are needed to treat toxoplasmosis. Toxoplasma gondii calcium-dependent protein kinases (TgCDPKs) are attractive targets because they are absent in mammals. We show that TgCDPK1 is inhibited by low nanomolar levels of bumped kinase inhibitors (BKIs), compounds designed to be inactive agains...

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Detalhes bibliográficos
Main Authors: Ojo, Kayode K, Larson, Eric T, Keyloun, Katelyn R, Castaneda, Lisa J, DeRocher, Amy E, Inampudi, Krishna K, Kim, Jessica E, Arakaki, Tracy L, Murphy, Ryan C, Zhang, Li, Napuli, Alberto J, Maly, Dustin J, Verlinde, Christophe LMJ, Buckner, Frederick S, Parsons, Marilyn, Hol, Wim GJ, Merritt, Ethan A, Van Voorhis, Wesley C
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896873/
https://ncbi.nlm.nih.gov/pubmed/20436472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1818
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