Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1

Calcium-dependent protein kinase-1 (CDPK1) from Cryptosporidium parvum (CpCDPK1) and Toxoplasma gondii (TgCDPK1) have become attractive targets for discovering selective inhibitors to combat infections caused by these protozoa. We used structure-based design to improve a series of benzoylbenzimidazo...

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Autors principals: Zhang, Zhongsheng, Ojo, Kayode K., Johnson, Steven M., Larson, Eric T., He, Penqing, Geiger, Jennifer A., Castellanos-Gonzalez, Alejandro, White, A. Clinton, Parsons, Marilyn, Merritt, Ethan A., Maly, Dustin J., Verlinde, Christophe L. M. J., Van Voorhis, Wesley C., Fan, Erkang
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420979/
https://ncbi.nlm.nih.gov/pubmed/22795629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.06.050
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