Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

[Image: see text] The protozoans Cryptosporidium parvum and Toxoplasma gondii are parasites of major health concern to humans. Both parasites contain a group of calcium-dependent protein kinases (CDPKs) which are found in plants and ciliates but not in humans or fungi. Here, we describe a series of...

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Main Authors: Murphy, Ryan C., Ojo, Kayode K., Larson, Eric T., Castellanos-Gonzalez, Alejandro, Perera, B. Gayani K., Keyloun, Katelyn R., Kim, Jessica E., Bhandari, Janhavi G., Muller, Natascha R., Verlinde, Christophe L. M. J., White, A. Clinton, Merritt, Ethan A., Van Voorhis, Wesley C., Maly, Dustin J.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2010
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992447/
https://ncbi.nlm.nih.gov/pubmed/21116453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100096t
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