Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity

Toxoplasmosis is a disease of prominent health concern that is caused by the protozoan parasite, Toxoplasma gondii. Proliferation of T. gondii is dependent on its ability to invade host cells, which is mediated, in part, by calcium-dependent protein kinase 1 (CDPK1). We have developed ATP competitiv...

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Autori principali: Johnson, Steven M., Murphy, Ryan C., Geiger, Jennifer A., DeRocher, Amy E., Zhang, Zhongsheng, Ojo, Kayode K., Larson, Eric T., Perera, B. Gayani K., Dale, Edward J., He, Panqing, Reid, Molly C., Fox, Anna M.W., Mueller, Natascha R., Merritt, Ethan A., Fan, Erkang, Parsons, Marilyn, Van Voorhis, Wesley C., Maly, Dustin J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306180/
https://ncbi.nlm.nih.gov/pubmed/22320388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201713h
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