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Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity

Toxoplasmosis is a disease of prominent health concern that is caused by the protozoan parasite, Toxoplasma gondii. Proliferation of T. gondii is dependent on its ability to invade host cells, which is mediated, in part, by calcium-dependent protein kinase 1 (CDPK1). We have developed ATP competitiv...

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Bibliographische Detailangaben
Hauptverfasser: Johnson, Steven M., Murphy, Ryan C., Geiger, Jennifer A., DeRocher, Amy E., Zhang, Zhongsheng, Ojo, Kayode K., Larson, Eric T., Perera, B. Gayani K., Dale, Edward J., He, Panqing, Reid, Molly C., Fox, Anna M.W., Mueller, Natascha R., Merritt, Ethan A., Fan, Erkang, Parsons, Marilyn, Van Voorhis, Wesley C., Maly, Dustin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306180/
https://ncbi.nlm.nih.gov/pubmed/22320388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201713h
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