In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum

We report on the in vitro effects of the bumped kinase inhibitor 1294 (BKI-1294) in cultures of virulent Neospora caninum isolates Nc-Liverpool (Nc-Liv) and Nc-Spain7 and in two strains of Toxoplasma gondii (RH and ME49), all grown in human foreskin fibroblasts. In these parasites, BKI-1294 acted wi...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Winzer, Pablo, Müller, Joachim, Aguado-Martínez, Adriana, Rahman, Mahbubur, Balmer, Vreni, Manser, Vera, Ortega-Mora, Luis Miguel, Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Van Voorhis, Wesley C., Hemphill, Andrew
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576114/
https://ncbi.nlm.nih.gov/pubmed/26248379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01236-15
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