Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites

We present the effects of two novel bumped kinase inhibitors, BKI-1517 and BKI-1553, against Neospora caninum tachyzoites in vitro and in experimentally infected pregnant mice. These compounds inhibited tachyzoite proliferation of a transgenic beta-galactosidase reporter strain cultured in human for...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Müller, Joachim, Aguado-Martínez, Adriana, Balmer, Vreni, Maly, Dustin J., Fan, Erkang, Ortega-Mora, Luis-Miguel, Ojo, Kayode K., Van Voorhis, Wesley C., Hemphill, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365725/
https://ncbi.nlm.nih.gov/pubmed/28137808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02324-16
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