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Structure of an apoptosome-procaspase-9 CARD complex
Apaf-1 co-assembles with cytochrome c to form the apoptosome, which then binds and activates procaspase-9. We removed pc-9 catalytic domains from the holo-apoptosome by site-directed thrombinolysis. A structure of the resulting apoptosome-pc-9 CARD complex was then determined at ~9.5Å resolution. In...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874686/ https://ncbi.nlm.nih.gov/pubmed/20462491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.04.001 |
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