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A near atomic structure of the Dark apoptosome provides insight into assembly and activation
In Drosophila, the Apaf-1 related killer (Dark) forms an apoptosome that activates procaspases. To investigate function, we have determined a near atomic structure of Dark double rings using cryo-electron microscopy. We then built a nearly complete model of the apoptosome that includes 7- and 8-blad...
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| Publicado en: | Structure |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5214966/ https://ncbi.nlm.nih.gov/pubmed/27916517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.11.002 |
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