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A near atomic structure of the active human apoptosome

In response to cell death signals, an active apoptosome is assembled from Apaf-1 and procaspase-9 (pc-9). Here we report a near atomic structure of the active human apoptosome determined by cryo-electron microscopy. The resulting model gives insights into cytochrome c binding, nucleotide exchange an...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Cheng, Tat Cheung, Hong, Chuan, Akey, Ildikó V, Yuan, Shujun, Akey, Christopher W
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050015/
https://ncbi.nlm.nih.gov/pubmed/27697150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17755
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