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Apoptosome structure, assembly and procaspase activation

Apaf-1 like molecules assemble into a ring-like platform known as the apoptosome. This cell death platform then activates procaspases in the intrinsic cell death pathway. In this review, crystal structures of Apaf-1 monomers and CED-4 dimers have been combined with apoptosome structures, to provide...

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Autors principals: Yuan, Shujun, Akey, Christopher W.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644875/
https://ncbi.nlm.nih.gov/pubmed/23561633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.02.024
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