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Apoptosome structure, assembly and procaspase activation
Apaf-1 like molecules assemble into a ring-like platform known as the apoptosome. This cell death platform then activates procaspases in the intrinsic cell death pathway. In this review, crystal structures of Apaf-1 monomers and CED-4 dimers have been combined with apoptosome structures, to provide...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3644875/ https://ncbi.nlm.nih.gov/pubmed/23561633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.02.024 |
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