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The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3
Activation of procaspase-9 on the apoptosome is a pivotal step in the intrinsic cell death pathway. We now provide further evidence that caspase recruitment domains of pc-9 and Apaf-1 form a CARD-CARD disk that is flexibly-tethered to the apoptosome. In addition, a 3D reconstruction of the pc-9 apop...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155825/ https://ncbi.nlm.nih.gov/pubmed/21827945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.07.001 |
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