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Structure of the Drosophila apoptosome at 6.9Å resolution
The Drosophila Apaf-1 related killer (Dark) forms an apoptosome in the intrinsic cell death pathway. In this study, we show that Dark forms a single-ring when initiator procaspases are bound. The resulting Dark-Dronc complex cleaves DrICE efficiently; hence, a single-ring represents the Drosophila a...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3053581/ https://ncbi.nlm.nih.gov/pubmed/21220123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.10.009 |
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