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Changes in Apaf-1 conformation that drive apoptosome assembly
Apoptosome assembly is highly regulated in the intrinsic cell death pathway. To better understand this step, we created an improved model of the human apoptosome using a crystal structure of full length Apaf-1 and a single particle, electron density map at ~9.5Å resolution. The apoptosome model incl...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3645920/ https://ncbi.nlm.nih.gov/pubmed/23521171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301721g |
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