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A New Model for the Transition of APAF-1 from Inactive Monomer to Caspase-activating Apoptosome
The cytosolic adaptor protein Apaf-1 is a key player in the intrinsic pathway of apoptosis. Binding of mitochondrially released cytochrome c and of dATP or ATP to Apaf-1 induces the formation of the heptameric apoptosome complex, which in turn activates procaspase-9. We have re-investigated the chai...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781688/ https://ncbi.nlm.nih.gov/pubmed/19801675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014027 |
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