A near atomic structure of the Dark apoptosome provides insight into assembly and activation

In Drosophila, the Apaf-1 related killer (Dark) forms an apoptosome that activates procaspases. To investigate function, we have determined a near atomic structure of Dark double rings using cryo-electron microscopy. We then built a nearly complete model of the apoptosome that includes 7- and 8-blad...

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Bibliographic Details
Published in:Structure
Main Authors: Cheng, Tat Cheung, Akey, Ildikó V., Yuan, Shujun, Yu, Zhiheng, Ludtke, Steven J., Akey, Christopher W.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214966/
https://ncbi.nlm.nih.gov/pubmed/27916517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.11.002
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