Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability

Human and other mammalian thymidylate synthase (TS) enzymes have an N-terminal extension of about 27 amino acids which is not present in bacterial TSs. The extension, which is disordered in all reported crystal structures of TSs, has been considered to play a primary role in protein turnover but not...

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Bibliographic Details
Main Authors: Huang, Xiao, Gibson, Lydia M., Bell, Brittnaie J., Lovelace, Leslie L., Peña, Maria Marjorette O., Berger, Franklin G., Berger, Sondra H., Lebioda, Lukasz
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856444/
https://ncbi.nlm.nih.gov/pubmed/20151707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901457e
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