A carregar...
Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding
Thymidylate synthase (TS) is a well validated target in cancer chemotherapy. Here, a new crystal form of the R163K variant of human TS (hTS) with five subunits per asymmetric part of the unit cell, all with loop 181–197 in the active conformation, is reported. This form allows binding studies by soa...
Na minha lista:
| Main Authors: | , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2011
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3016017/ https://ncbi.nlm.nih.gov/pubmed/21206062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910044732 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|