Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding

Thymidylate synthase (TS) is a well validated target in cancer chemotherapy. Here, a new crystal form of the R163K variant of human TS (hTS) with five subunits per asymmetric part of the unit cell, all with loop 181–197 in the active conformation, is reported. This form allows binding studies by soa...

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Hlavní autoři: Gibson, Lydia M., Celeste, Lesa R., Lovelace, Leslie L., Lebioda, Lukasz
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2011
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016017/
https://ncbi.nlm.nih.gov/pubmed/21206062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910044732
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