Variants of human thymidylate synthase with loop 181–197 stabilized in the inactive conformation

Loop 181–197 of human thymidylate synthase (hTS) populates two major conformations, essentially corresponding to the loop flipped by 180°. In one of the conformations, the catalytic Cys195 residue lies distant from the active site making the enzyme inactive. Ligands stabilizing this inactive conform...

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Bibliografiska uppgifter
Huvudupphovsmän: Lovelace, Leslie L, Johnson, Saphronia R, Gibson, Lydia M, Bell, Brittnaie J, Berger, Sondra H, Lebioda, Lukasz
Materialtyp: Artigo
Språk:Inglês
Publicerad: Wiley Subscription Services, Inc., A Wiley Company 2009
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776951/
https://ncbi.nlm.nih.gov/pubmed/19569192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.171
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