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Variants of human thymidylate synthase with loop 181–197 stabilized in the inactive conformation
Loop 181–197 of human thymidylate synthase (hTS) populates two major conformations, essentially corresponding to the loop flipped by 180°. In one of the conformations, the catalytic Cys195 residue lies distant from the active site making the enzyme inactive. Ligands stabilizing this inactive conform...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776951/ https://ncbi.nlm.nih.gov/pubmed/19569192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.171 |
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