טוען...
Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors
Thymidylate synthase (TS) is a target in the chemotherapy of colorectal cancer and some other neoplasms. It catalyses the transfer of a methyl group from methylenetrahydrofolate to dUMP to form dTMP. Based on structural considerations, we have introduced 1,3-propanediphosphonic acid (PDPA) as an all...
שמור ב:
| Main Authors: | , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2007
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516748/ https://ncbi.nlm.nih.gov/pubmed/17297914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061309j |
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