Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase

Thymidylate synthase (TS) catalyses the reductive methylation of dUMP to form dTMP, a reaction that is essential for maintenance of nucleotide pools during cell growth. Because the enzyme is indispensable for DNA replication in actively dividing cells, it is an important target for cytotoxic drugs u...

Full description

Saved in:
Bibliographic Details
Main Authors: Peña, Maria Marjorette O., Xing, Yang Yang, Koli, Sangita, Berger, Franklin G.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386034/
https://ncbi.nlm.nih.gov/pubmed/16259621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051479
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items