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Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase
Thymidylate synthase (TS) catalyses the reductive methylation of dUMP to form dTMP, a reaction that is essential for maintenance of nucleotide pools during cell growth. Because the enzyme is indispensable for DNA replication in actively dividing cells, it is an important target for cytotoxic drugs u...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1386034/ https://ncbi.nlm.nih.gov/pubmed/16259621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051479 |
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