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Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase
TS (thymidylate synthase) is a key enzyme in the de novo biosynthesis of dTMP, and is indispensable for DNA replication. Previous studies have shown that intracellular degradation of the human enzyme [hTS (human thymidylate synthase)] is mediated by the 26S proteasome, and occurs in a ubiquitin-inde...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549573/ https://ncbi.nlm.nih.gov/pubmed/23181752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120112 |
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