Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase

TS (thymidylate synthase) is a key enzyme in the de novo biosynthesis of dTMP, and is indispensable for DNA replication. Previous studies have shown that intracellular degradation of the human enzyme [hTS (human thymidylate synthase)] is mediated by the 26S proteasome, and occurs in a ubiquitin-inde...

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Bibliographic Details
Main Authors: Barbour, Karen W., Xing, Yang-Yang, Peña, Edsel A., Berger, Franklin G.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2013
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549573/
https://ncbi.nlm.nih.gov/pubmed/23181752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120112
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