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The Intrinsically Disordered N-terminal Domain of Thymidylate Synthase Targets the Enzyme to the Ubiquitin-independent Proteasomal Degradation Pathway

The ubiquitin-independent proteasomal degradation pathway is increasingly being recognized as important in regulation of protein turnover in eukaryotic cells. One substrate of this pathway is the pyrimidine biosynthetic enzyme thymidylate synthase (TS; EC 2.1.1.45), which catalyzes the reductive met...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Peña, Maria Marjorette O., Melo, Sandra P., Xing, Yang-Yang, White, Kenneth, Barbour, Karen W., Berger, Franklin G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797230/
https://ncbi.nlm.nih.gov/pubmed/19797058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038455
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