The Intrinsically Disordered N-terminal Domain of Thymidylate Synthase Targets the Enzyme to the Ubiquitin-independent Proteasomal Degradation Pathway

The ubiquitin-independent proteasomal degradation pathway is increasingly being recognized as important in regulation of protein turnover in eukaryotic cells. One substrate of this pathway is the pyrimidine biosynthetic enzyme thymidylate synthase (TS; EC 2.1.1.45), which catalyzes the reductive met...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Peña, Maria Marjorette O., Melo, Sandra P., Xing, Yang-Yang, White, Kenneth, Barbour, Karen W., Berger, Franklin G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Protein Synthesis, Post-Translational Modification, and Degradation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797230/
https://ncbi.nlm.nih.gov/pubmed/19797058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038455
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